I guess it’s another way of asking, “What event in your life had to most effective impact?”
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Birth of my first child. It wasn’t just life-changing because “now I’m a father” and such but he had heart disease and the first few months were really rough. It doubly reinforced that my time of being a big kid is over and I have to be an actual adult because lives can easily be ruined or lost by passing the buck and letting other people make my decisions for me.