I know food is everything, but is there been anything that helped you going down in weight other the food habits?
Right below that it says
Genetic factors play a crucial role in the development of gout, with several studies highlighting its strong hereditary component. Twin studies have demonstrated a strong genetic component in gout, with heritability estimates reaching 60% for uric acid kidney clearance, 87% for uric acid-to-creatinine ratios, and 28% to 31% for gout itself.
And also towards the end
While observational studies have often linked alcohol intake with gout, our MR analysis suggests that this association may be confounded by other factors or may not represent a direct causal relationship.
yeah, 100%. Not everybody gets gout, there is clearly a genetic profile that can develop gout… in the current metabolic context, and the modern diet.
People can’t control their genetics, they can control their metabolism, and their diet.
Fructose has uric acid as a byproduct of its metabolism [86]. Fructose induced hyperuricemia has a pathogenetic role in metabolic syndrome [78,87]. Higher insulin concentrations, associated with metabolic syndrome, reduce the renal excretion of uric acid [47,80,88]. Uric acid is an inhibitor of nitric oxide synthase, [78] which is the catalyst for nitric oxide, critical for circulatory and immune homeostasis.
Reducing circulating uric acid concentrations is one of the mechanistic components of improved blood pressure control that is observed with a reduction in fructose intake [89].
- Except from https://doi.org/10.1016/C2019-0-03604-7 section 7.3 Pathophysiology of gout
Here are the references
- 47 - https://doi.org/10.1016/j.semnephrol.2011.08.004
- 78 - https://doi.org/10.3899/jrheum.170806
- 80 - https://doi.org/10.1186/1758-5996-4-12
- 86 - https://doi.org/10.1152/physrev.00019.2009
- 87 - https://doi.org/10.1152/ajprenal.00140.2005
- 88 - https://doi.org/10.1001/jama.1991.03470210076036
- 89 - https://doi.org/10.1093/ajh/hpaa044
All of that is to say elevated uric acid is not the root of the problem, its a symptom of the core problem.
