Pharmaceuticals in the US. Fairly early in my career, get paid just short of $100k/year. All it took was getting a doctorate and selling a little bit of my soul.

Sometimes I miss academic research. But at the end of the day I’m getting paid about 4x as much while working 1/2 the hours, by my estimate I’m 8x as happy now. Plus, there’s something to be said for working on projects that actually affect people’s lives instead of overstating the impacts of my research to compete for a dwindling pool of federal grants. Seeing the policy changes in the US this year, I’m very glad I left academia but I’m not convinced I’m 100% safe from changes made at the FDA.

I love my Etymotics. Bit pricey but so comfortable. I wore them for years as a musician and now for live shows.

Unfortunately there’s a lot of truth in that statement, especially in the case of rare disease. It’s really difficult to convince a company to spend billions to develop a treatment that will only cure 1 in 100,000 people without letting them charge an arm and a leg, and giving them a very long exclusivity deal so they can continue to charge high prices. So much of that cost to develop is due to the dozens of other failed drugs and formulations they tried on their way to success.

I don’t have a solution for the problem, and I’m always a little suspicious of anyone who claims it’s easy to solve. I think the UK has a decent idea, the NHS basically decides if the cost of a drug will be covered by insurance by comparing the expected benefit and the current cost. If the ratio is too skewed, they refuse to cover the medication. In theory, this should be an incentive for a company to charge less. In practice, it leads to some companies choosing not to market in the UK.

Here’s a bit of hope for you, scientists have figured out how to trick the body into producing any protein or antibody they want, through technology like gene therapy and mRNA vaccines. We’re about to cure a lot of diseases that used to be 100% fatal. Diseases that kill kids and adults alike.

Most things seem to be getting worse these days, but at least we’re making progress in other areas.